Skroeder R, Jacobsson S, Kjellstrand P, Boberg U, Kjellstrand C M
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
ASAIO Trans. 1991 Jul-Sep;37(3):M129-32.
The authors varied urea clearance (K), dialysis time (T), and ultrafiltration (UF) in 294 hemodialyses on 23 patients and studied changes in urea space (V), determined by total dialysate urea removal. As K increased and UF and T decreased, V also decreased. K, T, and V, thus, covariate and dialysis adequacy, as studied by KT/V is not a simple function of three independent variables. Patients dialyzed quickly with little UF will need a higher KT/V than those dialyzed slowly with much UF.
作者在23例患者的294次血液透析中改变了尿素清除率（K）、透析时间（T）和超滤量（UF），并研究了通过总透析液尿素清除量确定的尿素分布容积（V）的变化。随着K增加以及UF和T降低，V也降低。因此，K、T和V存在协变量关系，并且如通过KT/V所研究的透析充分性并非三个独立变量的简单函数。与那些进行大量超滤且透析缓慢的患者相比，快速透析且超滤量少的患者将需要更高的KT/V。
