Czaja Albert J, Carpenter Herschel A, Moore S Breanndan
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street S.W, Rochester, MN 55905, USA.
Dig Dis Sci. 2008 Feb;53(2):522-8. doi: 10.1007/s10620-007-9859-4. Epub 2007 May 18.
Our goal was to determine if HLA DRB113 is associated with autoimmune hepatitis in North American patients. Two hundred and ten adults with definite type 1 autoimmune hepatitis were typed by DNA-based techniques, and the frequency of HLA DRB113 in patients without DRB103 and DRB104 was compared to that in 396 patients with eight other chronic liver diseases and 102 normal individuals. HLA DRB113 occurred more commonly in the autoimmune patients who lacked DRB103 and DRB104 than normal subjects who were similarly restricted (56% vs. 27%, P = 0.007). The frequency of HLA DRB113 was higher in autoimmune patients without DRB103 and DRB104 than in patients with other chronic liver diseases who were similarly restricted (59% vs. 32%, P = 0.01). Only patients with primary sclerosing cholangitis had a comparable occurrence of HLA DRB113. In conclusion, HLA DRB113 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.
我们的目标是确定HLA DRB113是否与北美患者的自身免疫性肝炎相关。采用基于DNA的技术对210例确诊为1型自身免疫性肝炎的成年人进行分型，并将无DRB103和DRB104的患者中HLA DRB113的频率与396例患有其他八种慢性肝病的患者及102例正常个体中的频率进行比较。在缺乏DRB103和DRB104的自身免疫性患者中，HLA DRB113的出现比同样受限的正常受试者更常见（56%对27%，P = 0.007）。在无DRB103和DRB104的自身免疫性患者中，HLA DRB113的频率高于同样受限的其他慢性肝病患者（59%对32%，P = 0.01）。只有原发性硬化性胆管炎患者HLA DRB113的出现率与之相当。总之，HLA DRB113可能是一些北美白人1型自身免疫性肝炎患者的遗传危险因素。
