Zouk Hana, McGirr Alexander, Lebel Véronique, Benkelfat Chawky, Rouleau Guy, Turecki Gustavo
McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada.
Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):996-1002. doi: 10.1002/ajmg.b.30521.
Impulsive-aggressive behaviors (IABs) are regarded as possible suicide intermediate phenotypes, mediating the relationship between genes and suicide outcome. In this study, we aimed to investigate the putative relationship between genetic variation at the 5-HT1B receptor gene, which in animal models is involved in impulse-aggression control, IABs, and suicide risk. We investigated the relationship of variation at five 5-HT1B loci and IAB measures in a sample of 696 subjects, including 338 individuals who died by suicide and 358 normal epidemiological controls. We found that variation at the 5-HT1B promoter A-161T locus had a significant effect on levels of IABs, as measured by the Buss-Durkee Hostility Inventory (BDHI). Suicides also differed from controls in distribution of variants at this locus. The A-161T locus, which seems to impact 5-HT1B transcription, could play a role in suicide predisposition by means of mediating impulsive-aggressive behaviors.
冲动攻击行为（IABs）被视为可能的自杀中间表型，介导基因与自杀结局之间的关系。在本研究中，我们旨在调查5-HT1B受体基因的遗传变异与冲动攻击行为及自杀风险之间的假定关系，在动物模型中该基因参与冲动攻击控制。我们在696名受试者的样本中研究了5个5-HT1B基因座的变异与冲动攻击行为测量指标之间的关系，其中包括338名自杀死亡者和358名正常流行病学对照者。我们发现，通过Buss-Durkee敌意量表（BDHI）测量，5-HT1B启动子A-161T基因座的变异对冲动攻击行为水平有显著影响。在该基因座的变异分布上，自杀者也与对照者不同。似乎影响5-HT1B转录的A-161T基因座可能通过介导冲动攻击行为在自杀易感性中起作用。
