Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary.
J Affect Disord. 2011 Aug;132(3):432-7. doi: 10.1016/j.jad.2011.03.029. Epub 2011 Apr 13.
The 5-HTTLPR polymorphism has been associated both with depression and aggression/hostility. The multidirectional association between depression, aggression and the s allele may be important, since all these phenomena are related to suicidal behavior. Our aim was to investigate the association between 5-HTTLPR and aggressive/hostile traits in depressed patients and controls.
137 depressive and 118 control women completed the Buss-Durkee Hostility Inventory and were genotyped for 5-HTTLPR. BDHI scores in the different groups were investigated by Generalized Linear Model Analysis. Association between dependent and independent variables in the model was tested by the likelihood ratio Chi-square statistic.
Diagnosis and genotype showed a significant association with several aggressive/hostile traits. Interaction of the two main effects was also significant in case of several subscales. Post hoc analyses indicated a significant association between BDHI subscales and s allele only in the depressed group.
Only women were studied and since gender differences are present both in aggressive behavior and putatively in the behavioral effects of 5-HTTLPR genotype, our findings pertain only to females.
Our results indicate a robust relationship between aggression/hostility and 5-HTTLPR genotype, but this association is more marked in the presence of depression. The presence of the s allele thus not only contributes to a higher risk of depression, but in depressives also leads to higher aggression/hostility. Our results have important implications for suicide research, since the s allele is associated with violent suicide, and this association may be mediated through the emergence of increased aggression/hostility in depressed patients carrying the s allele.
5-HTTLPR 多态性与抑郁和攻击/敌意都有关。抑郁、攻击和 s 等位基因之间的多向关联可能很重要，因为所有这些现象都与自杀行为有关。我们的目的是研究抑郁患者和对照组中 5-HTTLPR 与攻击/敌意特征之间的关联。
137 名抑郁女性和 118 名对照女性完成了 Buss-Durkee 敌意量表，并进行了 5-HTTLPR 基因分型。通过广义线性模型分析研究了不同组别的 BDHI 评分。通过似然比卡方检验统计量检验模型中因变量和自变量之间的关联。
诊断和基因型与几种攻击/敌意特征显著相关。两种主要效应的相互作用在几个亚量表中也很显著。事后分析表明，BDHI 亚量表与 s 等位基因之间仅在抑郁组中存在显著关联。
仅研究了女性，由于攻击性行为和假定的 5-HTTLPR 基因型的行为效应都存在性别差异，因此我们的发现仅适用于女性。
我们的结果表明，攻击性/敌意与 5-HTTLPR 基因型之间存在着强有力的关系，但这种关联在存在抑郁时更为明显。因此，s 等位基因不仅增加了患抑郁症的风险，而且在携带 s 等位基因的抑郁症患者中，还会导致更高的攻击性/敌意。我们的研究结果对自杀研究具有重要意义，因为 s 等位基因与暴力自杀有关，而这种关联可能通过增加携带 s 等位基因的抑郁患者的攻击性/敌意来介导。
