某些 1,4-二甲基咔唑类化合物对表达雌激素受体的细胞的抗增殖活性：第一部分。
Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I.
机构信息
Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS), Italy.
出版信息
J Enzyme Inhib Med Chem. 2012 Aug;27(4):609-13. doi: 10.3109/14756366.2011.603132. Epub 2011 Sep 2.
PMID:21883039
Abstract
Several 9H-carbazole derivatives are used for various pharmacological applications. Many of these compounds demonstrated cytotoxic and anticancer activities. In this work, we have investigated the cytotoxic activity of some substituted carbazoles against cancer cell lines (MCF-7, and ISK). The derivative 2a showed the highest inhibitory activity against both cell lines.
摘要
几种 9H-咔唑衍生物被用于各种药理学应用。许多这些化合物表现出细胞毒性和抗癌活性。在这项工作中，我们研究了一些取代咔唑衍生物对癌细胞系（MCF-7 和 ISK）的细胞毒性活性。衍生物 2a 对这两种细胞系表现出最高的抑制活性。
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