Han Quan-Bin, Qiao Chun-Feng, Song Jing-Zheng, Yang Nian-Yun, Cao Xin-Wei, Peng Yong, Yang Da-Jian, Chen Shi-Lin, Xu Hong-Xi
Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
Chem Biodivers. 2007 May;4(5):940-6. doi: 10.1002/cbdv.200790083.
Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.
从山竹的嫩枝树皮中分离出三种新的带有异戊烯基或香叶基取代基的羟基氧杂蒽酮化合物1-3，以及四种已知化合物1,4,5,6-四羟基-7,8-二异戊烯基氧杂蒽酮（4）、1,3,5,6-四羟基-4,7,8-三异戊烯基氧杂蒽酮（5）、山竹氧杂蒽酮E（6）和6-异戊烯基芹菜素（7）。通过广泛的光谱分析，包括一维和二维核磁共振以及高分辨质谱实验确定了它们的结构。所有化合物对乳腺癌（MDA-MB-435S）和肺腺癌（A549）细胞系均表现出中等细胞毒性，但对白色念珠菌缺乏抗真菌活性。
