Han Quan-Bing, Tian Hong-Lei, Yang Nian-Yun, Qiao Chun-Feng, Song Jing-Zheng, Chang Donald C, Luo Kathy Q, Xu Hong-Xi
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N. T., Hong Kong, P. R. China.
Chem Biodivers. 2008 Dec;5(12):2710-7. doi: 10.1002/cbdv.200890225.
Three new prenylated xanthones, 1-3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.
从长柄藤黄的茎皮中分离出三种新的异戊烯基呫吨酮(1-3)以及十种已知化合物。通过广泛的光谱分析,包括一维和二维核磁共振谱以及高分辨质谱实验对它们的结构进行了阐明。其中一些化合物对表达半胱天冬酶传感蛋白的宫颈癌细胞显示出凋亡作用或生长抑制作用。