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来自长柄藤黄的多异戊烯基呫吨酮对HeLa-C3细胞具有凋亡作用。

Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells.

作者信息

Han Quan-Bing, Tian Hong-Lei, Yang Nian-Yun, Qiao Chun-Feng, Song Jing-Zheng, Chang Donald C, Luo Kathy Q, Xu Hong-Xi

机构信息

Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N. T., Hong Kong, P. R. China.

出版信息

Chem Biodivers. 2008 Dec;5(12):2710-7. doi: 10.1002/cbdv.200890225.

DOI:10.1002/cbdv.200890225
PMID:19089829
Abstract

Three new prenylated xanthones, 1-3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.

摘要

从长柄藤黄的茎皮中分离出三种新的异戊烯基呫吨酮（1-3）以及十种已知化合物。通过广泛的光谱分析，包括一维和二维核磁共振谱以及高分辨质谱实验对它们的结构进行了阐明。其中一些化合物对表达半胱天冬酶传感蛋白的宫颈癌细胞显示出凋亡作用或生长抑制作用。

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