Bai Hong, Zhong Ying, Xie Yan-Ying, Wang Yuan-Shu, Liu Lu, Zhou Ling, Wang Ju, Mu Yan-Ling, Zuo Chun-Xu
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, PR China.
Chem Biodivers. 2007 May;4(5):955-60. doi: 10.1002/cbdv.200790085.
A new saponin, gypoldoside A (1), was isolated from the roots of Gypsophila oldhamiana. On the basis of in-depth NMR-spectroscopic and mass-spectrometric analysis, in combination with chemical evidence, its structure was established as 3-O-{beta-D-galactopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucuronopyranosyl}quillaic acid 28-[alpha-L-arabinopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranosyl] ester. Compound 1 was found to be highly active against three different human cancer cell lines, with IC50 values in the low micromolar range.
从老鹳草的根中分离出一种新的皂苷，即老鹳草苷A（1）。基于深入的核磁共振光谱和质谱分析，并结合化学证据，确定其结构为3 - O - {β - D - 吡喃半乳糖基 - （1→2） - [β - D - 吡喃木糖基 - （1→3）] - β - D - 吡喃葡萄糖醛酸基} 奎诺酸28 - [α - L - 吡喃阿拉伯糖基 - （1→2） - α - L - 吡喃阿拉伯糖基 - （1→3） - β - D - 吡喃木糖基 - （1→4） - α - L - 吡喃鼠李糖基 - （1→2） - β - D - 吡喃岩藻糖基] 酯。发现化合物1对三种不同的人类癌细胞系具有高活性，IC50值在低微摩尔范围内。
