[漏芦多糖对抗原刺激后小鼠免疫反应的影响及其可能机制]
[Effects of Rhaponticum uniforum polysaccharide on immune response of mice after antigen stimulation and their possible mechanisms].
作者信息
Li Fa-Sheng, Yang Guang, Xian Feng, Liu Hui
机构信息
College of Clinical Laboratory, Dalian Medical University, Dalian 116027, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(5):433-5.
OBJECTIVE
To study the effects of Rhaponticum uniforum polysaccharide on immune function in normal mice and the underlying mechanism.
METHOD
SRBC and ovalbumin were employed as antigens to be injected to mice, respectively. Three doses of R. uniforum polysaccharide (50, 100, 200 mg x kg(-1) x d(-1)) were given orally for seven days. After the secondary immunization, the level of corresponding antibody and the concentration of serum IL-2, IFN-gamma were determined.
RESULT
The levels of antibodies (anti-SRBC and anti-ovalbumin) and cytokines (IL-2 and IFN-gamma) in median dose group of R. uniforum polysaccharide were all significantly higher than those in control groups (P <0.05).
CONCLUSION
R. uniforum polysaccharide could enhance the immune function in normal mice.
目的
研究祁州漏芦多糖对正常小鼠免疫功能的影响及其潜在机制。
方法
分别采用绵羊红细胞（SRBC）和卵清蛋白作为抗原注射到小鼠体内。给予祁州漏芦多糖三个剂量（50、100、200mg·kg⁻¹·d⁻¹），连续口服七天。二次免疫后，测定相应抗体水平及血清白细胞介素-2（IL-2）、干扰素-γ（IFN-γ）浓度。
结果
祁州漏芦多糖中剂量组的抗体（抗SRBC和抗卵清蛋白）水平及细胞因子（IL-2和IFN-γ）水平均显著高于对照组（P<0.05）。
结论
祁州漏芦多糖可增强正常小鼠的免疫功能。
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