Devasena T, Venugopal Menon P
Department of Biotechnology, Mother Teresa Women's University, Kodaikanal, Tamil Nadu, India.
Ital J Biochem. 2007 Mar;56(1):28-34.
1,2-dimethylhydrazine (DMH) is a colon carcinogen which undergoes oxidative metabolism in the liver. We have investigated the modulatory effect of fenugreek seeds (a spice) on colon tumor incidence as well as hepatic lipid peroxidation (LPO) and antioxidant status during DMH-induced colon carcinogenesis in male Wistar rats. In DMH treated rats, 100% colon tumor incidence was accompanied by enhanced LPO and a decrease in reduced glutathione (GSH) content as well as a fall in glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activities. Inclusion of fenugreek seed powder in the diet of DMH treated rats reduced the colon tumor incidence to 16.6%, decreased the LPO and increased the activities of GPx, GST, SOD and CAT in the liver. We report that fenugreek modulates DMH-induced hepatic oxidative stressduring colon cancer
1,2 - 二甲基肼（DMH）是一种结肠致癌物，在肝脏中进行氧化代谢。我们研究了胡芦巴籽（一种香料）对雄性Wistar大鼠在DMH诱导的结肠癌发生过程中结肠肿瘤发生率以及肝脏脂质过氧化（LPO）和抗氧化状态的调节作用。在DMH处理的大鼠中，100%的结肠肿瘤发生率伴随着LPO增强、还原型谷胱甘肽（GSH）含量降低以及谷胱甘肽过氧化物酶（GPx）、谷胱甘肽S - 转移酶（GST）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性下降。在DMH处理大鼠的饮食中添加胡芦巴籽粉可将结肠肿瘤发生率降低至16.6%，降低LPO，并增加肝脏中GPx、GST、SOD和CAT的活性。我们报道胡芦巴在结肠癌发生过程中可调节DMH诱导的肝脏氧化应激
