Ash S R, Blake D E, Carr D J, Carter C, Howard T, Makowka L
St. Elizabeth Hospital, Lafayette, Indiana.
ASAIO Trans. 1991 Jul-Sep;37(3):M332-4.
Fifteen patients with acute deterioration of liver function, high serum ammonia, and an average coma level of 3.9 (of 4) were treated for 8-12 hrs daily with a system that uses the membranes of a cellulosic plate dialyzer to pump blood through a single access at 200-225 ml/min, and includes a sorbent suspension as dialysate. Neurologic status of the patients was declining before treatment, but significantly improved during each treatment and over the course of 1-12 (average, 4) treatments. Diastolic blood pressure and pulse rate normalized. For half the patients, treatment with the BioLogic-DT system served as a bridge to liver transplant or liver recovery.
15例肝功能急性恶化、血清氨水平高且昏迷程度平均为3.9级（满分4级）的患者，每天使用一种系统进行8至12小时的治疗。该系统利用纤维素平板透析器的膜，以200至225毫升/分钟的速度通过单一通路泵血，并包含一种吸附剂悬浮液作为透析液。患者的神经状态在治疗前呈下降趋势，但在每次治疗期间及1至12次（平均4次）治疗过程中显著改善。舒张压和脉搏率恢复正常。对于半数患者，使用BioLogic-DT系统进行治疗成为肝移植或肝脏恢复的桥梁。
