Bigot Sarah, Sivanathan Viknesh, Possoz Christophe, Barre François-Xavier, Cornet François
Laboratoire de Microbiologie et de Génétique Moléculaire du CNRS, Université Paul Sabatier--Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex, France.
Mol Microbiol. 2007 Jun;64(6):1434-41. doi: 10.1111/j.1365-2958.2007.05755.x. Epub 2007 May 18.
The study of chromosome segregation in bacteria has gained strong insights from the use of cytology techniques. A global view of chromosome choreography during the cell cycle is emerging, highlighting as a next challenge the description of the molecular mechanisms and factors involved. Here, we review one of such factor, the FtsK DNA translocase. FtsK couples segregation of the chromosome terminus, the ter region, with cell division. It is a powerful and fast translocase that reads chromosome polarity to find the end, thereby sorting sister ter regions on either side of the division septum, and activating the last steps of segregation. Recent data have revealed the structure of the FtsK motor, how translocation is oriented by specific DNA motifs, termed KOPS, and suggests novel mechanisms for translocation and sensing chromosome polarity.
细菌中染色体分离的研究通过使用细胞学技术获得了深刻见解。细胞周期中染色体编排的全局视图正在浮现，这凸显了描述其中涉及的分子机制和因素作为下一个挑战。在此，我们综述其中一个因素，即FtsK DNA转位酶。FtsK将染色体末端（ter区域）的分离与细胞分裂联系起来。它是一种强大且快速的转位酶，能读取染色体极性以找到末端，从而将姐妹ter区域分选到分裂隔膜两侧，并激活分离的最后步骤。最近的数据揭示了FtsK马达的结构、转位如何由特定的DNA基序（称为KOPS）定向，并提出了转位和感知染色体极性的新机制。
