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Blood-brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses.利用分子特洛伊木马实现蛋白质和非病毒基因治疗药物的血脑屏障递送。
J Control Release. 2007 Oct 8;122(3):345-8. doi: 10.1016/j.jconrel.2007.04.001. Epub 2007 Apr 6.
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Drug targeting to the brain.药物靶向大脑。
Pharm Res. 2007 Sep;24(9):1733-44. doi: 10.1007/s11095-007-9324-2. Epub 2007 Jun 7.
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Re-engineering biopharmaceuticals for delivery to brain with molecular Trojan horses.利用分子特洛伊木马对生物制药进行重新设计以实现向大脑的递送。
Bioconjug Chem. 2008 Jul;19(7):1327-38. doi: 10.1021/bc800148t. Epub 2008 Jun 12.
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Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology.利用分子木马技术将生物制剂递送到血脑屏障。
BioDrugs. 2017 Dec;31(6):503-519. doi: 10.1007/s40259-017-0248-z.
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Blood-brain barrier molecular trojan horse enables imaging of brain uptake of radioiodinated recombinant protein in the rhesus monkey.血脑屏障分子木马使放射性碘标记重组蛋白在恒河猴脑摄取的成像成为可能。
Bioconjug Chem. 2013 Oct 16;24(10):1741-9. doi: 10.1021/bc400319d. Epub 2013 Oct 3.
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Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier.重新设计生物制药以实现跨血脑屏障的靶向递送。
Methods Enzymol. 2012;503:269-92. doi: 10.1016/B978-0-12-396962-0.00011-2.
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Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody.利用转铁蛋白受体单克隆抗体进行IgG融合蛋白的血脑屏障药物递送
Expert Opin Drug Deliv. 2015 Feb;12(2):207-22. doi: 10.1517/17425247.2014.952627. Epub 2014 Aug 20.
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Biopharmaceutical drug targeting to the brain.生物制药药物靶向脑部。
J Drug Target. 2010 Apr;18(3):157-67. doi: 10.3109/10611860903548354.
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Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier.一种人类神经营养因子与一种用于穿越人类血脑屏障的分子特洛伊木马融合蛋白的基因工程、表达及活性
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Targeted delivery of protein and gene medicines through the blood-brain barrier.通过血脑屏障实现蛋白质和基因药物的靶向递送。
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Inorganic Nanoparticles-based Drug Delivery Systems for Neurodegenerative Diseases Therapy.用于神经退行性疾病治疗的无机纳米颗粒药物递送系统
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The Mechanism and Latest Research Progress of Blood-Brain Barrier Breakthrough.血脑屏障突破的机制及最新研究进展
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Advances in Intrathecal Nanoparticle Delivery: Targeting the Blood-Cerebrospinal Fluid Barrier for Enhanced CNS Drug Delivery.鞘内纳米颗粒递送的进展：靶向血脑脊髓液屏障以增强中枢神经系统药物递送
Pharmaceuticals (Basel). 2024 Aug 15;17(8):1070. doi: 10.3390/ph17081070.
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Autophagy-associated non-coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis.自噬相关非编码 RNA：揭示其对帕金森病发病机制的影响。
CNS Neurosci Ther. 2024 May;30(5):e14763. doi: 10.1111/cns.14763.
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Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route.探索纳米制剂经鼻途径治疗阿尔茨海默病的潜力。
Curr Alzheimer Res. 2024;21(10):693-709. doi: 10.2174/0115672050290462240222092303.
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Endocrine Regulation of Microvascular Receptor-Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9-Mediated Regulation.微血管受体介导的转胞吞作用的内分泌调节及其治疗机会：PCSK9介导的调节见解
Pharmaceutics. 2023 Apr 18;15(4):1268. doi: 10.3390/pharmaceutics15041268.
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CNS Delivery of Nucleic Acid Therapeutics: Beyond the Blood-Brain Barrier and Towards Specific Cellular Targeting.中枢神经系统递药：超越血脑屏障和迈向特定细胞靶向。
Pharm Res. 2023 Jan;40(1):77-105. doi: 10.1007/s11095-022-03433-5. Epub 2022 Nov 15.
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Nanoparticle delivery systems for substance use disorder.用于物质使用障碍的纳米颗粒递药系统。
Neuropsychopharmacology. 2022 Jul;47(8):1431-1439. doi: 10.1038/s41386-022-01311-7. Epub 2022 Mar 28.
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Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier.靶向非编码RNA治疗胶质母细胞瘤：克服血脑屏障的挑战
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Effects of pulse parameters on the temperature distribution of a human head exposed to the electromagnetic pulse.脉冲参数对人体头部暴露在电磁脉冲下的温度分布的影响。
Sci Rep. 2021 Nov 25;11(1):22938. doi: 10.1038/s41598-021-02396-8.
本文引用的文献
1
Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation.用于阿尔茨海默病的融合抗体，具有双向穿越血脑屏障和β淀粉样蛋白原纤维解聚的功能。
Bioconjug Chem. 2007 Mar-Apr;18(2):447-55. doi: 10.1021/bc060349x. Epub 2007 Feb 22.
2
Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier.一种人类神经营养因子与一种用于穿越人类血脑屏障的分子特洛伊木马融合蛋白的基因工程、表达及活性
Biotechnol Bioeng. 2007 Aug 15;97(6):1376-86. doi: 10.1002/bit.21369.
3
Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier.用于跨越人血脑屏障进行药物靶向的抗人胰岛素受体抗体人源化
Biotechnol Bioeng. 2007 Feb 1;96(2):381-91. doi: 10.1002/bit.21120.
4
Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion.脑源性神经营养因子的血脑屏障靶向作用改善大脑中动脉闭塞大鼠的运动功能。
Brain Res. 2006 Sep 21;1111(1):227-9. doi: 10.1016/j.brainres.2006.07.005. Epub 2006 Aug 1.
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Imaging gene expression in regional brain ischemia in vivo with a targeted [111in]-antisense radiopharmaceutical.使用靶向[111铟]反义放射性药物在体内对局部脑缺血中的基因表达进行成像。
Mol Imaging. 2004 Oct;3(4):356-63. doi: 10.1162/15353500200404145.
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Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor.通过血脑屏障转铁蛋白受体将β-半乳糖苷酶递送至小鼠脑内。
J Pharmacol Exp Ther. 2005 Jun;313(3):1075-81. doi: 10.1124/jpet.104.082974. Epub 2005 Feb 17.
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Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer.靶向人类表皮生长因子受体的静脉内RNA干扰基因疗法可延长颅内脑癌患者的生存期。
Clin Cancer Res. 2004 Jun 1;10(11):3667-77. doi: 10.1158/1078-0432.CCR-03-0740.
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Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter.采用静脉内非病毒基因疗法及脑特异性启动子使实验性帕金森病纹状体酪氨酸羟化酶正常化并逆转运动障碍
Hum Gene Ther. 2004 Apr;15(4):339-50. doi: 10.1089/104303404322959498.
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Gene targeting in vivo with pegylated immunoliposomes.聚乙二醇化免疫脂质体的体内基因靶向
Methods Enzymol. 2003;373:507-28. doi: 10.1016/S0076-6879(03)73032-8.
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