对氧磷酶1（PON1）是心血管疾病的一种新生物标志物，在系统性血管炎患者中水平较低。

PON1, a new biomarker of cardiovascular disease, is low in patients with systemic vasculitis.

作者信息

Quéméneur Thomas, Martin-Nizard Françoise, Kandoussi Abdelmejid, Kyndt Xavier, Vanhille Philippe, Hachulla Eric, Hatron Pierre-Yves, Fruchart Jean-Charles, Duriez Patrick, Lambert Marc

机构信息

Department of Nephrology and Internal Medicine, Hospital of Valenciennes, Valenciennes, France.

出版信息

Semin Arthritis Rheum. 2007 Dec;37(3):149-55. doi: 10.1016/j.semarthrit.2007.03.002. Epub 2007 May 21.

DOI:10.1016/j.semarthrit.2007.03.002

PMID:17512573

Abstract

OBJECTIVES

Because systemic vasculitis (SV) predisposes to atherosclerosis, and high-density lipoprotein (HDL) prevents atherosclerosis by "reverse cholesterol transport" and by inhibiting low-density lipoprotein (LDL) oxidation thanks to apolipoprotein A-I (Apo-AI) and paraoxonase 1 (PON1), we assessed whether LDL oxidation was increased in SV and associated with less PON1 activity.

METHODS

The sera of 33 patients with active SV (ASV), 32 in full remission of SV (RSV) and 20 healthy subjects (HS) were analyzed for C-reactive protein (CRP), high-sensitivity-CRP, lipids, lipoproteins, apolipoproteins, PON1 activity, LDL-immune complexes (LDL-IC), and auto-antibodies to oxidized-LDL (ox-LDL), and anticardiolipin antibodies.

RESULTS

CRP was higher in ASV than RSV and HS, and negatively correlated with HDL-cholesterol and Apo-AI. Autoantibodies to ox-LDL and highly oxidized malondialdehyde-LDL were higher in RSV than ASV and HS (P<0.05). LDL-IC titers were higher in ASV than RSV and HS (P<0.05). PON1 activity was lower in ASV and RSV than HS (P=0.02). A trend toward a negative correlation between basal PON1 activity and anti-MDA-LDL antibodies (P=0.06) was observed.

CONCLUSION

Inflammatory markers in SV were associated with a modified lipoprotein profile, which could lower PON1 activity and contribute to increased ox-LDL titers and accelerated atherosclerosis development.

摘要

目的

由于系统性血管炎（SV）易患动脉粥样硬化，而高密度脂蛋白（HDL）通过“逆向胆固醇转运”以及借助载脂蛋白A-I（Apo-AI）和对氧磷酶1（PON1）抑制低密度脂蛋白（LDL）氧化来预防动脉粥样硬化，我们评估了SV患者的LDL氧化是否增加以及是否与PON1活性降低有关。

方法

分析了33例活动性SV（ASV）患者、32例SV完全缓解（RSV）患者和20名健康受试者（HS）的血清，检测C反应蛋白（CRP）、高敏CRP、血脂、脂蛋白、载脂蛋白、PON1活性、LDL免疫复合物（LDL-IC）、氧化LDL（ox-LDL）自身抗体和抗心磷脂抗体。

结果

ASV患者的CRP高于RSV患者和HS，且与HDL胆固醇和Apo-AI呈负相关。RSV患者中ox-LDL和高度氧化的丙二醛-LDL自身抗体高于ASV患者和HS（P<0.05）。ASV患者的LDL-IC滴度高于RSV患者和HS（P<0.05）。ASV患者和RSV患者的PON1活性低于HS（P=0.02）。观察到基础PON1活性与抗MDA-LDL抗体之间存在负相关趋势（P=0.06）。