González Ana I, Brites Fernando, Elbert Alicia, Gómez-Rosso Leonardo, Berg Gabriela, Wikinski Regina, Schreier Laura
Laboratorio de Lípidos y Lipoproteínas, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica - INFIBIOC, Universidad de Buenos Aires, Argentina.
Medicina (B Aires). 2010;70(6):508-12.
Advanced Chronic Renal Disease (CKD) is closely associated with a pro-inflammatory condition, with an increase in triglyceride-rich lipoproteins and decrease in HDL level. HDL contains antioxidant enzymes such as paraoxonase (PON), whose activity is diminished in CKD. The aim of our study was to evaluate the relationship between PON activity with HDL cholesterol, apo A1 and hs-CRP levels, which are known to be inflammatory markers in hemodialyzed patients. Forty-two patients were studied; age, median (range) = 50 (25-67) years old, gender M/F = 22/20, duration of hemodialysis = 4.4 ± 0.5 years, BMI: 23 ± 0.5 kg/m2. After a 12 h fast, a blood sample was obtained and classic components of lipid profile were determined, as well as apoproteins A1 and B, PON by means of its arylsterase activity and hs-CRP levels. On the basis of the latter, patients were divided into two groups: hs-CRP ≤ 1 (low risk, range: 0.1 to 1.0 mg/l) and > 1 mg/l (moderate and high risk, 1.1 to 10.7 mg/l). No difference was found in triglycerides, LDL cholesterol and apo B in the groups. Patients with hs-CRP > 1 showed lower HDL cholesterol (40 ± 2 mg/dl) and apo A1 (118 ± 4 mg/dl) than patients with hs-CRP ≤ 1 (50 ± 4 and 133 ± 5, respectively); p < 0.05. PON was lower in hs-CRP > 1 = 90.5 ± 24.0 µmol/ml.min than in hs-CRP ≤ 1 = 105.2 ± 18.0. Consequently, inverse correlations were obtained between apo A1 and hs-CRP, r = -0.381, p = 0.013 and between PON and hs-CRP, r = -0.32, p = 0.042. Furthermore, increase in hs-CRP correlated positively with BMI r = 0.318, p = 0.042. Since apo A1 has an anti-inflammatory role and PON an antioxidant activity, the decrease in HDL and its components, cholesterol, apo A1 and PON, in subjects with higher chronic inflammatory condition might explain, in part, the increased cardiovascular risk in these patients.
晚期慢性肾脏病（CKD）与促炎状态密切相关，富含甘油三酯的脂蛋白增加而高密度脂蛋白（HDL）水平降低。HDL含有抗氧化酶如对氧磷酶（PON），其活性在CKD中降低。我们研究的目的是评估PON活性与HDL胆固醇、载脂蛋白A1和超敏C反应蛋白（hs-CRP）水平之间的关系，这些已知是血液透析患者的炎症标志物。对42例患者进行了研究；年龄，中位数（范围）=50（25 - 67）岁，性别男/女=22/20，血液透析时间=4.4±0.5年，体重指数（BMI）：23±0.5kg/m²。禁食12小时后，采集血样并测定血脂谱的经典成分，以及载脂蛋白A1和B、通过其芳基酯酶活性测定的PON和hs-CRP水平。基于后者，将患者分为两组：hs-CRP≤1（低风险，范围：0.1至1.0mg/l）和>1mg/l（中度和高风险，1.1至10.7mg/l）。两组在甘油三酯、低密度脂蛋白胆固醇和载脂蛋白B方面未发现差异。hs-CRP>1的患者的HDL胆固醇（40±2mg/dl）和载脂蛋白A1（118±4mg/dl）低于hs-CRP≤1的患者（分别为50±就，0.05。hs-CRP>1组的PON（90.5±24.0μmol/ml·min）低于hs-CRP≤1组（105.2±18.0）。因此，载脂蛋白A1与hs-CRP之间呈负相关，r = -0.381，p = 0.013；PON与hs-CRP之间呈负相关，r = -0.32，p = 0.042。此外，hs-CRP的升高与BMI呈正相关，r = 0.318，p = 0.042。由于载脂蛋白A1具有抗炎作用而PON具有抗氧化活性，慢性炎症状态较高的受试者中HDL及其成分胆固醇、载脂蛋白A1和PON的降低可能部分解释了这些患者心血管风险的增加。 4和133±5）；p<4mg/dl和apo A1（118±4mg/dl）低于hs-CRP≤1的患者（分别为50±4和133±5）；p<0.05。hs-CRP>1组的PON（90.5±24.0μmol/ml·min）低于hs-CRP≤1组（105.2±18.0）。因此，载脂蛋白A1与hs-CRP之间呈负相关，r = -0.381，p = 0.013；PON与hs-CRP之间呈负相关，r = -0.32，p = 0.042。此外，hs-CRP的升高与BMI呈正相关，r = 0.318，p = 0.042。由于载脂蛋白A1具有抗炎作用而PON具有抗氧化活性，慢性炎症状态较高的受试者中HDL及其成分胆固醇、载脂蛋白A1和PON的降低可能部分解释了这些患者心血管风险的增加。
译文中存在一些格式和重复表述上不太准确的地方，原文可能存在一些小错误，但大致翻译内容如上。
