食蟹猴针对麻疹病毒的免疫反应。

Immune responses against measles virus in cynomolgus monkeys.

作者信息

Sato Hiroki, Kobune Fumio, Ami Yasushi, Yoneda Misako, Kai Chieko

机构信息

Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

出版信息

Comp Immunol Microbiol Infect Dis. 2008 Jan;31(1):25-35. doi: 10.1016/j.cimid.2007.03.003. Epub 2007 May 21.

DOI:10.1016/j.cimid.2007.03.003

PMID:17512593

Abstract

Measles virus (MV) induces profound suppression of the immune response during and for weeks after acute infection. On the other hand, virus-specific immune responses that mediate viral clearance and confer long-lasting immunity are efficiently generated. To investigate this paradox, we studied the immune responses to MV using a monkey model of acute measles. Cynomolgus monkeys were experimentally infected with wild-type MV (MV-HL) and showed marked leukopenia associated with a steady reduction in CD4+ T cell numbers for 18 days post-inoculation. Transient expression of interferon and IL-6 were observed in the serum between 4 and 6 days post-inoculation, and IL-10 levels increased after 11 days post-inoculation. Interestingly, IL-8 showed a three-peak increase that correlated with an increase in neutrophils. A non-human primate model of measles allows the early immune response against MV to be studied in more detail.

摘要

麻疹病毒（MV）在急性感染期间及感染后的数周内会引发免疫反应的深度抑制。另一方面，介导病毒清除并赋予持久免疫力的病毒特异性免疫反应也能有效产生。为了探究这一矛盾现象，我们使用急性麻疹的猴子模型研究了对MV的免疫反应。食蟹猴经实验感染野生型MV（MV-HL），接种后18天出现明显的白细胞减少，同时CD4+ T细胞数量持续减少。接种后4至6天血清中观察到干扰素和IL-6的短暂表达，接种后11天IL-10水平升高。有趣的是，IL-8呈现出三个峰值的增加，这与中性粒细胞的增加相关。麻疹的非人灵长类动物模型有助于更详细地研究针对MV的早期免疫反应。