Agarwal Mukesh Kumar, Iqbal Mohammad, Athar Mohammad
Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, India.
Food Chem Toxicol. 2007 Sep;45(9):1634-40. doi: 10.1016/j.fct.2007.02.029. Epub 2007 Feb 28.
Intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA) to rats and mice results in iron-induced free radical injury and cancer in kidneys. This study was designed to investigate the effects of garlic oil on Fe-NTA-induced damage and tumor promotion. Pretreatment of rats with garlic oil at a dose regimen of 50-100 mg/kg body weight for a week significantly and dose dependently protected against Fe-NTA induced damage as well as tumor promotion. Garlic oil afforded protection against hepatic lipid peroxidation, generation of hydrogen peroxide, preserved glutathione levels and activities of antioxidant enzymes. A protection against Fe-NTA induced hepatic tumor promotion was also apparent as inhibition in the modulation of hepatic tumor markers viz., ornithine decarboxylase activity and DNA synthesis. These results clearly demonstrate the role of oxidative stress and its relation to tumor promotion and suggest protective effects of garlic oil against Fe-NTA induced hepatic toxicity and it can serve as potent chemopreventive agent to suppress oxidant-induced tissue injury and carcinogenesis.
给大鼠和小鼠腹腔注射次氮基三乙酸铁（Fe-NTA）会导致铁诱导的自由基损伤和肾脏癌症。本研究旨在调查大蒜油对Fe-NTA诱导的损伤和肿瘤促进作用的影响。以50 - 100毫克/千克体重的剂量方案用大蒜油预处理大鼠一周，可显著且剂量依赖性地保护其免受Fe-NTA诱导的损伤以及肿瘤促进作用。大蒜油可防止肝脂质过氧化、过氧化氢的产生，维持谷胱甘肽水平和抗氧化酶的活性。对Fe-NTA诱导的肝肿瘤促进作用的保护也很明显，表现为对肝肿瘤标志物即鸟氨酸脱羧酶活性和DNA合成调节的抑制。这些结果清楚地证明了氧化应激的作用及其与肿瘤促进的关系，并表明大蒜油对Fe-NTA诱导的肝毒性具有保护作用，它可作为一种有效的化学预防剂来抑制氧化剂诱导的组织损伤和致癌作用。
