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花青素在小鼠哮喘模型中可抑制气道炎症和高反应性。

Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model.

作者信息

Park Sang-Joon, Shin Won-Ho, Seo Joung-Wook, Kim Eun-Joo

机构信息

Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Yuseong, Daejeon 305-600, Republic of Korea.

出版信息

Food Chem Toxicol. 2007 Aug;45(8):1459-67. doi: 10.1016/j.fct.2007.02.013. Epub 2007 Feb 20.

Abstract

Asthma is a common chronic inflammatory disease regulated by coordination of T-helper cell type 2 (Th2) cytokines and inflammatory signal molecules. Additionally, oxidative stress may play an important role in airway inflammation such as eosinophilia, mucus hypersecretion, and airway hyperresponsiveness (AHR). In the present report, we investigated whether anthocyanins would reduce airway inflammation in a mouse asthma model immunized and challenged with ovalbumin (OVA). OVA inhalation elicited inflammatory responses characterized by eosinophilia and increased lipid hydroperoxide (LPO) in bronchoalveolar lavage (BAL) fluid, enhanced pause (Penh), increased glycoprotein and proliferating cell nuclear antigen (PCNA) expressions in mucus hypersecretion, and an increased expression of various cytokines and cyclooxygenase (COX) 2 in lung tissues. All parameters were attenuated in a dose-dependant manner by the administration of anthocyanins. These results suggest that anthocyanins may attenuate the development of asthma by downregulating Th2 cytokines, proinflammatory cytokines, and COX-2. Our findings suggest that anthocyanins have positive contributions as a dietary supplement for the prevention of asthma.

摘要

哮喘是一种常见的慢性炎症性疾病,由2型辅助性T细胞(Th2)细胞因子和炎症信号分子协同调节。此外,氧化应激可能在气道炎症中发挥重要作用,如嗜酸性粒细胞增多、黏液高分泌和气道高反应性(AHR)。在本报告中,我们研究了花青素是否会减轻卵清蛋白(OVA)免疫和激发的小鼠哮喘模型中的气道炎症。吸入OVA引发了炎症反应,其特征为嗜酸性粒细胞增多、支气管肺泡灌洗(BAL)液中脂质过氧化氢(LPO)增加、增强暂停(Penh)、黏液高分泌中糖蛋白和增殖细胞核抗原(PCNA)表达增加,以及肺组织中各种细胞因子和环氧化酶(COX)2表达增加。通过给予花青素,所有参数均呈剂量依赖性减弱。这些结果表明,花青素可能通过下调Th2细胞因子、促炎细胞因子和COX-2来减轻哮喘的发展。我们的研究结果表明,花青素作为预防哮喘的膳食补充剂具有积极作用。

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