School of Health Sciences, Caritas Institute of Higher Education, Hong Kong SAR 999077, China.
Faculty of Medicine, Macau University of Science & Technology, Macau 853, China.
Molecules. 2020 Apr 3;25(7):1653. doi: 10.3390/molecules25071653.
Metabolic syndrome is a cluster of interrelated conditions that is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Oxidative stress may impair normal physiological functions, leading to various illnesses. T2DM is considered to be associated with increased oxidative stress, inflammation, and dyslipidemia, which may play a significant role in the development of cardiovascular complications, cancer and vision loss through cataracts and retinopathy. While conventional therapies are a cornerstone for the management of the major risk factors of metabolic syndrome, increasing antioxidant defense by increasing intake of antioxidant-rich foods may improve long term prospects in CVD, obesity and T2DM. Bilberry ( ) is one of the richest natural sources of anthocyanins which give berries their red/purple/blue coloration. Anthocyanins are powerful antioxidants and are reported to play an important role in the prevention of metabolic disease and CVD as well as cancer and other conditions. This review focuses on the potential effects of bilberry supplementation on metabolic and cardiovascular risk factors. Although there is evidence to support the use of bilberry supplementation as part of a healthy diet, the potential benefits from the use of bilberry supplementation in patients with T2DM or CVD needs to be clarified in large clinical trials.
代谢综合征是一组相互关联的病症，与心血管疾病 (CVD) 和 2 型糖尿病 (T2DM) 的风险增加有关。氧化应激可能会损害正常的生理功能，导致各种疾病。T2DM 被认为与氧化应激增加、炎症和血脂异常有关，这些可能在心血管并发症、癌症以及白内障和视网膜病变导致的视力丧失的发展中发挥重要作用。虽然传统疗法是治疗代谢综合征主要危险因素的基石，但通过增加富含抗氧化剂的食物的摄入来增加抗氧化防御能力，可能会改善 CVD、肥胖和 T2DM 的长期前景。欧洲越桔（Vaccinium myrtillus）是花青素含量最丰富的天然来源之一，使浆果呈现出红色/紫色/蓝色。花青素是一种强大的抗氧化剂，据报道在预防代谢疾病和 CVD 以及癌症和其他疾病方面发挥着重要作用。本文综述了欧洲越桔补充剂对代谢和心血管危险因素的潜在影响。尽管有证据支持将欧洲越桔补充剂作为健康饮食的一部分，但需要在大型临床试验中阐明在 T2DM 或 CVD 患者中使用欧洲越桔补充剂的潜在益处。
