大麻槿中木脂素的细胞毒性活性。

Cytotoxic activity of lignans from Hibiscus cannabinus.

作者信息

Moujir Laila, Seca Ana M L, Silva Artur M S, López Manuel R, Padilla Nayely, Cavaleiro José A S, Neto Carlos P

机构信息

Department of Microbiology and Cellular Biology, and Instituto Canario de Investigación del Cáncer, University of La Laguna, 38206 La Laguna, Tenerife, Spain.

出版信息

Fitoterapia. 2007 Jul;78(5):385-7. doi: 10.1016/j.fitote.2007.03.010. Epub 2007 Apr 11.

DOI:10.1016/j.fitote.2007.03.010

PMID:17512680

Abstract

The antimicrobial and cytotoxic activities of six lignans isolated from the core and bark acetone extracts of Hibiscus cannabinus have been investigated. Two compounds (2 and 3) showed strong cytotoxic activity against HeLa, Hep-2 and A-549 cell lines while compound 5 showed moderate activity on HeLa cells when they were in advanced stage of cellular division. The compounds did not exhibit antimicrobial activity.

摘要

对从大麻槿的茎芯和树皮丙酮提取物中分离出的六种木脂素的抗菌和细胞毒性活性进行了研究。两种化合物（2和3）对HeLa、Hep-2和A-549细胞系表现出较强的细胞毒性活性，而化合物5在细胞分裂后期对HeLa细胞表现出中等活性。这些化合物未表现出抗菌活性。