Yamamoto Hiroshi, Teramoto Shinji, Yamaguchi Yasuhiro, Hanaoka Yoko, Ishii Masaki, Hibi Shinichiro, Ouchi Yasuyoshi
Department of Geriatric Medicine, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Sleep Med. 2007 Dec;9(1):80-7. doi: 10.1016/j.sleep.2007.02.002. Epub 2007 May 18.
Obstructive sleep apnea syndrome (OSAS) is recognized as one of the risk factors of hypertension and cardiovascular disorders. In the current study, we hypothesized that the hypoxic stress caused by obstructive sleep apnea would increase circulating adrenomedullin (ADM) levels in untreated OSAS patients compared to an age-matched control group. We further hypothesized that oxygen administration treatment may decrease OSAS-induced hypoxic stress and ADM levels.
We examined short-term and long-term oxygen administration effects on circulating ADM in 48 OSAS patients.
The circulating levels of ADM in untreated OSAS patients were significantly greater than those in the controls. We did not observe a significant effect in 2 weeks of oxygen administration on the circulating ADM in the patients, but we observed a significant effect in long-term oxygen administration for more than 3 months on plasma ADM levels. Long-term oxygen therapy decreased both the magnitude of arterial oxygen desaturation and plasma ADM levels in patients but did not decrease blood pressure.
These observations suggest that long-term oxygen therapy could reduce OSAS-induced nocturnal hypoxemia and plasma ADM levels in patients with OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）被认为是高血压和心血管疾病的危险因素之一。在本研究中，我们假设与年龄匹配的对照组相比，阻塞性睡眠呼吸暂停引起的低氧应激会增加未经治疗的OSAS患者循环中的肾上腺髓质素（ADM）水平。我们进一步假设吸氧治疗可能会减轻OSAS引起的低氧应激并降低ADM水平。
我们研究了48例OSAS患者短期和长期吸氧对循环中ADM的影响。
未经治疗的OSAS患者循环中的ADM水平显著高于对照组。我们未观察到吸氧2周对患者循环中ADM有显著影响，但观察到长期（超过3个月）吸氧对血浆ADM水平有显著影响。长期氧疗降低了患者动脉血氧饱和度下降的幅度和血浆ADM水平，但未降低血压。
这些观察结果表明，长期氧疗可减轻OSAS患者夜间低氧血症和血浆ADM水平。
