Teramoto Shinji, Kume Haruki, Yamamoto Hiroshi, Ishii Takeo, Miyashita Akira, Matsuse Takeshi, Akishita Masahiro, Toba Kenji, Ouchi Yasuyoshi
Department of Geriatric Medicine, The University of Tokyo Hospital, Tokyo.
Intern Med. 2003 Aug;42(8):681-5. doi: 10.2169/internalmedicine.42.681.
Repeated nocturnal hypoxia is implicated in the pathogenesis of cardiovascular complications in obstructive sleep apnea syndrome (OSAS). We hypothesized that circulating vascular endothelial growth factor (VEGF) levels are affected by nocturnal hypoxemia in patients with OSAS.
We examined the serum VEGF levels in patients with OSAS and in control subjects. We also tested the effects of oxygen or air administration on the subjects' VEGF levels.
Twenty-four OSAS patients (mean age 54.2 +/- 3.6 years) and 24 age-matched control subjects (53.2 +/- 3.6 years). Their serum samples were tested.
Serum VEGF levels at 8:00 AM were significantly higher in OSAS patients than in controls (p<0.01). VEGF levels decreased from 515 +/- 31 (pg/ml) to 178 +/- 16 (pg/m) (p<0.01) in OSAS patients whose nocturnal hypoxemia was found to be improved by administration of 2 l/min of oxygen during the night. However, the administration of compressed air affected neither the VEGF level nor nocturnal oxygen desaturation in OSAS patients.
These results indicate that circulating VEGF levels are elevated in OSAS patients, primarily due to nocturnal hypoxemia.
反复夜间低氧血症与阻塞性睡眠呼吸暂停综合征（OSAS）心血管并发症的发病机制有关。我们假设OSAS患者循环血管内皮生长因子（VEGF）水平受夜间低氧血症影响。
我们检测了OSAS患者和对照受试者的血清VEGF水平。我们还测试了给予氧气或空气对受试者VEGF水平的影响。
24例OSAS患者（平均年龄54.2±3.6岁）和24例年龄匹配的对照受试者（53.2±3.6岁）。检测了他们的血清样本。
上午8点时，OSAS患者的血清VEGF水平显著高于对照组（p<0.01）。在夜间给予2升/分钟氧气后夜间低氧血症得到改善的OSAS患者中，VEGF水平从515±31（pg/ml）降至178±16（pg/ml）（p<0.01）。然而，给予压缩空气对OSAS患者的VEGF水平和夜间氧饱和度均无影响。
这些结果表明，OSAS患者循环VEGF水平升高，主要是由于夜间低氧血症。
