一种用于评估雄性性功能的新型小鼠模型。
A novel mouse model for assessment of male sexual function.
作者信息
Soukhova-O'Hare G K, Schmidt M H, Nozdrachev A D, Gozal D
机构信息
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA.
出版信息
Physiol Behav. 2007 Aug 15;91(5):535-43. doi: 10.1016/j.physbeh.2007.04.016.
A novel model to evaluate erectile, ejaculatory, and sexual behavior patterns in conscious mouse is presented. Corpus spongiosum of the penis (CSP) pressure was recorded by using telemetry and was correlated with erectile activity (penile elongations, cups, flips) during reflex induction and spontaneous erections in freely moving mice. CSP pressure was also recorded during mating tests (mounts, intromissions with erections, ejaculations), as well as non-contact tests with estrous female mice. Erectile events were quantified in four sexual contexts (spontaneous erections, spinal reflexes, in mating and non-contact tests). The data demonstrate that CSP pressure monitoring is a valid technique for assessment of sexual function in freely moving mice.
本文提出了一种评估清醒小鼠勃起、射精和性行为模式的新型模型。通过遥测技术记录阴茎海绵体（CSP）压力，并将其与自由活动小鼠在反射诱导和自发勃起期间的勃起活动（阴茎伸长、弯曲、翻转）相关联。在交配试验（骑跨、勃起插入、射精）以及与发情期雌性小鼠的非接触试验中也记录了CSP压力。在四种性情境（自发勃起、脊髓反射、交配和非接触试验）中对勃起事件进行了量化。数据表明，CSP压力监测是评估自由活动小鼠性功能的有效技术。
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