McRae J, Hambright P, Valk P, Bearden A J
J Nucl Med. 1976 Mar;17(3):208-11.
Sodium gluconate transforms the bone-seekers 99mTc-HEDP and 99mTc-pyrophosphate into the renal agent 99mTc-gluconate. In these in vitro processes, pyrophosphate is displaced faster than HEDP, while the HEDP reaction is accelerated by calcium ions. The in vivo distributions of these bone and kidney agents are altered by the prior local injection of calcium or iron(II). These transformation and translocation phenomena are explained in terms of the mechanistic behavior of Tc(IV) complexes.
葡萄糖酸钠可将亲骨性放射性药物99mTc - HEDP和99mTc - 焦磷酸盐转化为肾显像剂99mTc - 葡萄糖酸盐。在这些体外过程中，焦磷酸盐的取代速度比HEDP快，而钙离子可加速HEDP的反应。预先局部注射钙或亚铁会改变这些骨显像剂和肾显像剂的体内分布。这些转化和移位现象可根据Tc(IV)配合物的作用机制来解释。
