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细胞周期调控与皮层发育

Cell-cycle control and cortical development.

作者信息

Dehay Colette, Kennedy Henry

机构信息

INSERM, U846, 18 Avenue Doyen Lépine, 69675 Bron Cedex, France.

出版信息

Nat Rev Neurosci. 2007 Jun;8(6):438-50. doi: 10.1038/nrn2097.

Abstract

The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps.

摘要

最后一轮有丝分裂的时空定时,随后神经母细胞迁移至皮质板,导致形成了六层皮质,该皮质又被细分为功能明确的皮质区域。尽管在啮齿动物中已经确立了许多细胞和分子机制,但在灵长类动物中仍有一些独特特征需要进一步阐明。最近在啮齿动物和灵长类动物中的研究发现表明,细胞周期的调控,特别是G1期的调控,在控制区域特异性神经元产生速率和细胞构筑图的形成中起着关键作用。

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