Hansen Ted H, Huang Shouxiong, Arnold Phoebe L, Fremont Daved H
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
Nat Immunol. 2007 Jun;8(6):563-8. doi: 10.1038/ni1475.
The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immune responses rely on T cell clonal expansion that develops in response to variable peptides bound to the groove of classical major histocompatibility complex (MHC) proteins. For certain nonclassical 'MHC-like' class Ib proteins, such as H2-M3 and CD1d, their respective binding grooves seem to have been adapted to present to T cells unique molecular patterns analogous to those involved in innate signaling. Here we propose that another MHC class Ib protein, MR1, which is required for the gut flora-dependent development of mucosa-associated invariant T cells, presents either a microbe-produced or a microbe-induced pattern.
对进化上保守的化学物质（通常源自病原体）部分有选择性反应的模式识别受体的鉴定，为先天免疫细胞如何促进快速且相对特异性的抗菌免疫活动提供了关键见解。相比之下，适应性免疫反应相对较慢，它依赖于T细胞克隆扩增，这种扩增是针对与经典主要组织相容性复合体（MHC）蛋白凹槽结合的可变肽而产生的。对于某些非经典的“I类MHC样”Ib类蛋白，如H2-M3和CD1d，它们各自的结合凹槽似乎已经适应于向T细胞呈递类似于先天信号传导中涉及的独特分子模式。在此我们提出，另一种MHC Ib类蛋白MR1，它是黏膜相关恒定T细胞肠道菌群依赖性发育所必需的，呈递一种微生物产生的或微生物诱导的模式。
