Rodgers John R, Cook Richard G
Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
Nat Rev Immunol. 2005 Jun;5(6):459-71. doi: 10.1038/nri1635.
Our understanding of the classical MHC class I molecules (MHC class Ia molecules) has long focused on their extreme polymorphism. These molecules present peptides to T cells and are central to discrimination between self and non-self. By contrast, the functions of the non-polymorphic MHC class I molecules (MHC class Ib molecules) have been elusive, but emerging evidence reveals that, in addition to antigen presentation, MHC class Ib molecules are involved in immunoregulation. As we discuss here, the subset of MHC class Ib molecules that presents peptides to T cells bridges innate and acquired immunity, and this provides insights into the origins of acquired immunity.
长期以来，我们对经典的MHC I类分子（MHC Ia类分子）的理解一直聚焦于其极端的多态性。这些分子将肽段呈递给T细胞，是区分自身与非自身的核心。相比之下，非多态性的MHC I类分子（MHC Ib类分子）的功能一直难以捉摸，但新出现的证据表明，除了抗原呈递外，MHC Ib类分子还参与免疫调节。正如我们在此所讨论的，向T细胞呈递肽段的MHC Ib类分子亚群连接了固有免疫和获得性免疫，这为了解获得性免疫的起源提供了线索。
