缺氧诱导因子在癌症中的作用。
The role of hypoxia-inducible factors in cancer.
作者信息
Maynard M A, Ohh M
机构信息
Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, M5S1A8, Toronto, Ontario, Canada.
出版信息
Cell Mol Life Sci. 2007 Aug;64(16):2170-80. doi: 10.1007/s00018-007-7082-2.
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that mediates the adaptive responses to hypoxia by effecting the transcription of numerous hypoxia-inducible genes. HIF is frequently overexpressed in solid tumors, and the transactivation of HIF targets in transformed cells provides a distinct survival advantage. Accordingly, the upregulation of HIF correlates with increased progression or aggressiveness of the cancer and poor prognosis. In addition to the induction of HIF by hypoxia, its expression is induced by the loss of tumor suppressors VHL, PTEN, TSC1/2, PML, and SDH, as well as by the increased activity of PI3K and/or MAPK signaling pathways, underscoring the significance of HIF in oncogenesis.
缺氧诱导因子（HIF）是一种异二聚体转录因子，它通过影响众多缺氧诱导基因的转录来介导对缺氧的适应性反应。HIF在实体瘤中经常过度表达，并且其在转化细胞中的靶标的反式激活提供了明显的生存优势。因此，HIF的上调与癌症进展加快或侵袭性增加以及预后不良相关。除了缺氧诱导HIF外，肿瘤抑制因子VHL、PTEN、TSC1/2、PML和SDH的缺失以及PI3K和/或MAPK信号通路活性增加也可诱导其表达，这突出了HIF在肿瘤发生中的重要性。
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