Simion Massimo, Rocchietta Isabella, Dellavia Claudia
Department of Periodontology, Institute for Dental Research and Education, University of Milan, Italy.
Int J Periodontics Restorative Dent. 2007 Apr;27(2):109-15.
The present paper reports on two patients who underwent three-dimensional ridge augmentation using a xenograft in combination with recombinant human platelet-derived growth factor-BB (rhPDGF-BB). Patient 1 received a deproteinized bovine block infused with PDGF and secured to the alveolar crest by two fixation screws to augment the crest horizontally. After 5 months, implants were successfully placed. Patient 2 underwent a vertical ridge augmentation procedure that combined deproteinized bovine bone particles embedded in a collagen matrix soaked in PDGF Three titanium dental implants were placed in each patient 5 months later. Clinical and histologic results showed excellent soft and hard tissue healing. Bone had regenerated throughout the whole area and the xenograft particles were embedded in bone, which presented resorption lacunae close to areas with ongoing bone formation. This indicated that, in augmented areas, intense physiologic remodeling was ongoing. No data exist concerning three-dimensional bone augmentation using PDGF and a xenograft in humans. This report suggests that the use of rhPDGF-BB in combination with a deproteinized bovine graft may have the potential to regenerate large three-dimensional alveolar defects in humans.
本文报道了两名患者，他们接受了使用异种移植物联合重组人血小板衍生生长因子-BB（rhPDGF-BB）进行的三维牙槽嵴增高术。患者1接受了注入PDGF的脱蛋白牛骨块，并通过两颗固定螺钉固定于牙槽嵴以水平增高牙槽嵴。5个月后，成功植入种植体。患者2接受了垂直牙槽嵴增高术，该手术将嵌入浸有PDGF的胶原基质中的脱蛋白牛骨颗粒相结合。5个月后，为每位患者植入了三颗牙科钛种植体。临床和组织学结果显示软组织和硬组织愈合良好。整个区域均有骨再生，异种移植物颗粒嵌入骨中，在正在形成骨的区域附近出现吸收陷窝。这表明，在增高的区域，正在进行强烈的生理性重塑。目前尚无关于在人类中使用PDGF和异种移植物进行三维骨增高的相关数据。本报告表明，rhPDGF-BB与脱蛋白牛移植物联合使用可能有潜力在人类中再生大型三维牙槽骨缺损。
