Curry Andrew S, Pensa Nicholas W, Barlow Abby M, Bellis Susan L
Department of Biomedical Engineering, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, United States.
Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, United States.
Matrix Biol. 2016 May-Jul;52-54:397-412. doi: 10.1016/j.matbio.2016.02.011. Epub 2016 Mar 2.
There is an ongoing need for effective materials that can replace autologous bone grafts in the clinical treatment of bone injuries and deficiencies. In recent years, research efforts have shifted away from a focus on inert biomaterials to favor scaffolds that mimic the biochemistry and structure of the native bone extracellular matrix (ECM). The expectation is that such scaffolds will integrate with host tissue and actively promote osseous healing. To further enhance the osteoinductivity of bone graft substitutes, ECM-mimetic scaffolds are being engineered with a range of growth factors (GFs). The technologies used to generate GF-modified scaffolds are often inspired by natural processes that regulate the association between endogenous ECMs and GFs. The purpose of this review is to summarize research centered on the development of regenerative scaffolds that replicate the fundamental collagen-hydroxyapatite structure of native bone ECM, and the functionalization of these scaffolds with GFs that stimulate critical events in osteogenesis.
在骨损伤和骨缺损的临床治疗中，一直需要能够替代自体骨移植的有效材料。近年来，研究工作已从专注于惰性生物材料转向青睐模仿天然骨细胞外基质（ECM）生物化学和结构的支架。期望此类支架能与宿主组织整合并积极促进骨愈合。为进一步提高骨移植替代物的骨诱导性，正在用一系列生长因子（GFs）设计模仿ECM的支架。用于生成GF修饰支架的技术通常受到调节内源性ECM与GFs之间关联的自然过程的启发。本综述的目的是总结围绕开发复制天然骨ECM基本胶原 - 羟基磷灰石结构的再生支架以及用刺激骨生成关键事件的GFs对这些支架进行功能化的研究。
