Lavoie C, Jolicoeur M, Paiement J
Département d'anatomie, Faculté de médecine, Université de Montréal, Québec, Canada.
Biochim Biophys Acta. 1991 Nov 18;1070(1):274-8. doi: 10.1016/0005-2736(91)90175-8.
The accumulation of polyunsaturated free fatty acids (PUFAs) was observed coincident with GTP-dependent fusion of liver rough microsomes. Whereas 0.5 mM NADPH led to a parallel reduction (greater than 50%) in membrane fusion and PUFA accumulation, indomethacin (50 microM) either had little effect or slightly augmented both processes. CTP was observed to stimulate accumulation of PUFAs and diacylglycerol (DAG). Therefore PUFAs may be relevant for GTP-dependent membrane fusion and together with DAG may play a role in fusion stimulated in the presence of CTP.
