Esen Berrin, Kurtoglu Demet, Coplu Nilay, Gozalan Aysegul, Miyamura Kikuko, Ishida Setsuji, Akin Levent
Communicable Diseases Research Department, Refik Saydam National Hygiene Center, Ankara, Turkey.
Jpn J Infect Dis. 2007 May;60(2-3):92-6.
In order to assess the effect of the neonatal tetanus elimination program in Turkey, tetanus antibody prevalence among women of childbearing age from three selected provinces was evaluated in relation to vaccination doses of the single-type tetanus vaccine. A combined method of in-house enzyme-linked immunosorbent assay and particle agglutination test was used to determine tetanus antibody titers. Among 205 women aged 20-39 years, the tetanus antibody level was higher in women with 1-3 children than those without children. The geometric mean of the log antibody titer was increased proportionally with a slope of 0.405 +/- 0.174 per dose between 0 and 3 doses (P > 0.05). However, the proportion of 20-39-year-old women with the protective antibody in the provinces ranged from 54.8 to 86.6%. Diyarbakir had the lowest immunity with a larger number of children in the household, and a lower educational level. The results of our serological study demonstrated that the neonatal tetanus elimination program in Turkey is effectively promoting immunity against tetanus in pregnant women. However, the study also revealed that the tetanus immunity among women of childbearing age was still insufficient. Intensive implementation of the supplemental immunization activities and encouraging vaccinations through neonatal care services will improve the situation.
为评估土耳其新生儿破伤风消除计划的效果，针对来自三个选定省份的育龄妇女，根据单价破伤风疫苗的接种剂量评估了破伤风抗体流行情况。采用内部酶联免疫吸附测定和颗粒凝集试验相结合的方法来测定破伤风抗体滴度。在205名20至39岁的妇女中，有1至3个孩子的妇女的破伤风抗体水平高于无子女的妇女。在0至3剂之间，对数抗体滴度的几何平均值每剂以0.405±0.174的斜率成比例增加（P>0.05）。然而，这些省份中20至39岁有保护性抗体的妇女比例在54.8%至86.6%之间。迪亚巴克尔的免疫力最低，家庭中孩子数量较多，且教育水平较低。我们的血清学研究结果表明，土耳其的新生儿破伤风消除计划正在有效提高孕妇对破伤风的免疫力。然而，该研究还表明，育龄妇女的破伤风免疫力仍然不足。强化实施补充免疫活动并通过新生儿护理服务鼓励接种疫苗将改善这种情况。
