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[一名类圆线虫病患者并发肾病综合征和革兰氏阴性菌败血症:病例报告]

[Nephrotic syndrome and Gram-negative sepsis in a patient with strongyloidiasis: a case report].

作者信息

Rotolo Ugo, Scarlata Francesco, Giordano Salvatore, Tortorici Calogera, Bono Luisa, Coglitore Mario, Faraci Cesare, Infurnari Laura, Rubino Raffaella, Romano Amelia

机构信息

U.O. di Nefrologia e Dialisi - A.R.N.A.S. Civico- Palermo, Italy.

出版信息

Infez Med. 2007 Mar;15(1):59-62.

Abstract

Strongyloidiasis is caused by a small intestinal nematode with a complex life cycle. In Italy the infection is endemic in rural areas of the Po Valley. The clinical syndrome of S. stercoralis encompasses a broad spectrum of symptoms and signs and, in the immunocompromised host, larvae can migrate to different organs and tissues. Also immune response seems to play a role in the pathogenesis of the disease. We report a case of strongyloidiasis complicated by Gram-negative sepsis and nephrotic syndrome in an immigrant from South America with a normal immune response. Whereas sepsis cleared up quickly, parasitic clearance was obtained only after treatment with ivermectin and nephrotic syndrome was still present three months after the end of treatment.

摘要

类圆线虫病由一种具有复杂生命周期的小肠线虫引起。在意大利,波河流域农村地区存在该感染的地方性流行。粪类圆线虫的临床综合征包括广泛的症状和体征,在免疫功能低下的宿主中,幼虫可迁移至不同器官和组织。免疫反应似乎也在该疾病的发病机制中起作用。我们报告了一例来自南美的移民患类圆线虫病并伴有革兰氏阴性菌败血症和肾病综合征的病例,其免疫反应正常。败血症很快得到清除,但仅在使用伊维菌素治疗后才实现寄生虫清除,并且在治疗结束三个月后肾病综合征仍然存在。

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