Guo Jiasong, Zeng Yuanshan, Liang Yuxiang, Wang Li, Su Huanxing, Wu Wutain
Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Neuroreport. 2007 Jun 11;18(9):863-8. doi: 10.1097/WNR.0b013e32811d6d36.
Cyclosporine is one of the foremost immunosuppressive agents for cell, tissue, and organ transplantation. Cyclosporine is, however, associated with significant side effects in the host, and may also affect the fate of the donor cells. This study was performed to test whether cyclosporine may change the fate of neural stem cells, as neural stem cell transplant has become a potential treatment for neurological disorders and damage. Results of this study showed that cyclosporine inhibited the proliferation significantly in a dosage-dependent manner. Cyclosporine also affected the differentiation of neural stem cells, which mainly increased astrocyte genesis and decreased neuron differentiation.
环孢素是细胞、组织和器官移植中最重要的免疫抑制剂之一。然而，环孢素会给宿主带来显著的副作用，还可能影响供体细胞的命运。由于神经干细胞移植已成为治疗神经系统疾病和损伤的一种潜在方法，因此开展了本研究以测试环孢素是否会改变神经干细胞的命运。本研究结果表明，环孢素以剂量依赖性方式显著抑制增殖。环孢素还影响神经干细胞的分化，主要是增加星形胶质细胞生成并减少神经元分化。
