Szuba M P, Baxter L R, Fairbanks L A, Guze B H, Schwartz J M
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine.
Biol Psychiatry. 1991 Oct 15;30(8):817-29. doi: 10.1016/0006-3223(91)90237-g.
Partial sleep deprivation (PSD), keeping a subject awake from 2 AM to 9 PM produces an acute mood improvement in 60% of patients with major depression. We sought to characterize the timing, subcomponent mood, and motor activity changes of this response. Thirty-seven subjects with major depression were rated with the 6-item Hamilton Depression Scale (HAM-6) at 1 PM and completed the Profile of Mood States (POMS) every 2 hr on the day before and day of PSD. Locomotor activity was monitored continuously during the trial with an automated device. Bipolar I patients responded more frequently than other groups. Positive mood responders had greater improvement than nonresponders in POMS subscales of depression, tension, confusion, and anger. The mood improvement increased steadily during the day, peaked in late afternoon, and declined thereafter. Responders showed significantly higher levels of locomotor activity on the baseline pre-PSD day than did nonresponders. All subjects increased motor activity following sleep deprivation, however.
部分睡眠剥夺（PSD），即让受试者从凌晨2点到晚上9点保持清醒，会使60%的重度抑郁症患者的情绪得到急性改善。我们试图描述这种反应的时间、情绪子成分和运动活动变化。37名重度抑郁症患者在下午1点接受6项汉密尔顿抑郁量表（HAM-6）评估，并在PSD前一天和当天每2小时完成一次情绪状态剖面图（POMS）。在试验期间，使用自动化设备连续监测运动活动。双相I型患者的反应比其他组更频繁。在POMS的抑郁、紧张、困惑和愤怒子量表中，积极情绪反应者比无反应者有更大的改善。情绪改善在白天稳步增加，在傍晚达到峰值，此后下降。反应者在PSD前一天的基线时的运动活动水平明显高于无反应者。然而，所有受试者在睡眠剥夺后运动活动都增加了。
