阿仑单抗治疗后隐球菌免疫重建炎症综合征

Cryptococcal immune reconstitution inflammatory syndrome following alemtuzumab therapy.

作者信息

Ingram Paul R, Howman Rebecca, Leahy Michael F, Dyer John R

机构信息

Department of Infectious Diseases, Fremantle Hospital, Fremantle, Western Australia, Australia.

出版信息

Clin Infect Dis. 2007 Jun 15;44(12):e115-7. doi: 10.1086/518168. Epub 2007 May 2.

DOI:10.1086/518168

PMID:17516390

Abstract

Alemtuzumab is a lymphocyte ablative agent that may cause susceptibility to severe opportunistic infections similar to those seen in AIDS. Pathogen-specific immune reconstitution syndromes can complicate antiretroviral therapy and immune recovery in HIV-infected patients. We present the first reported case of immune reconstitution syndrome associated with T lymphocyte recovery after alemtuzumab therapy.

摘要

阿仑单抗是一种淋巴细胞清除剂，可能导致患者易患严重的机会性感染，类似于艾滋病患者所见的感染情况。病原体特异性免疫重建综合征可能使HIV感染患者的抗逆转录病毒治疗和免疫恢复复杂化。我们报告了首例经阿仑单抗治疗后与T淋巴细胞恢复相关的免疫重建综合征病例。