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粒细胞集落刺激因子用于低分化生殖细胞瘤患者后引发隐球菌性脑膜炎免疫重建炎症综合征的病例报告

Unmasking Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome due to Granulocyte Colony-Stimulating Factor Use in a Patient with a Poorly Differentiated Germ Cell Neoplasm.

作者信息

Bahr Nathan C, Wallace James, Frosch Anne E P, Boulware David R

机构信息

Department of MedicineCenter for Infectious Diseases and Microbiology Translational Research, Minn., USA ; Center for Infectious Diseases and Microbiology Translational Research, Minn., USA ; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minn., USA.

Department of MedicineCenter for Infectious Diseases and Microbiology Translational Research, Minn., USA.

出版信息

Case Rep Oncol. 2014 Jan 11;7(1):1-5. doi: 10.1159/000357666. eCollection 2014 Jan.

Abstract

Cryptococcal meningitis immune reconstitution inflammatory syndrome (IRIS) is frequently seen in patients with HIV and less frequently in patients on immune suppressive medications for other conditions. Here, we describe the first reported case of unmasking cryptococcal IRIS due to granulocyte colony-stimulating factor used in an HIV-negative patient with chemotherapy-induced neutropenia.

摘要

隐球菌性脑膜炎免疫重建炎症综合征(IRIS)在艾滋病患者中常见,而在因其他疾病接受免疫抑制治疗的患者中较少见。在此,我们描述了首例因粒细胞集落刺激因子引发的隐球菌性IRIS病例,该病例发生在一名因化疗导致中性粒细胞减少的HIV阴性患者身上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c7/3934776/abe615d8a774/cro-0007-0001-g01.jpg

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