Tortorella Alfonso, Monteleone Palmiero, Martiadis Vassilis, Perris Francesco, Maj Mario
Department of Psychiatry, University of Naples SUN, Naples, Italy.
Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):992-5. doi: 10.1002/ajmg.b.30508.
Feeding is subjected to circadian regulation; therefore, changes in the components of the endogenous oscillator regulating circadian rhythms may be involved in disordered rhythmicity of eating behavior as it occurs in anorexia nervosa (AN) and bulimia nervosa (BN). We investigated whether the 3111T/C polymorphism of the CLOCK gene, which is part of the endogenous oscillator system, was associated to AN and/or BN. A total of 241 women, including 90 healthy controls, 60 patients with AN and 91 patients with BN, participated into the study. The frequencies of 3111T/C genotypes and alleles did not significantly differ among the groups. In both the AN and BN group, subjects carrying one copy of the C allele had a lifetime body weight significantly lower than those carrying the T/T genotype. These findings, although preliminary, suggest that the 3111T/C polymorphism of the CLOCK gene does not play a major role in the genetic vulnerability to AN and BN, but it seems to predispose eating disorders (EDs) patients to a more severe lifetime body weight loss.
进食受昼夜节律调节；因此，调节昼夜节律的内源性振荡器组成部分的变化可能与神经性厌食症（AN）和神经性贪食症（BN）中出现的进食行为节律紊乱有关。我们研究了作为内源性振荡器系统一部分的CLOCK基因的3111T/C多态性是否与AN和/或BN相关。共有241名女性参与了该研究，其中包括90名健康对照者、60名AN患者和91名BN患者。3111T/C基因型和等位基因的频率在各组之间没有显著差异。在AN组和BN组中，携带一份C等位基因的受试者终生体重均显著低于携带T/T基因型的受试者。这些发现虽然是初步的，但表明CLOCK基因的3111T/C多态性在AN和BN的遗传易感性中不发挥主要作用，但似乎使饮食失调（EDs）患者更容易出现更严重的终生体重减轻。
