Genotype Is Associated with Increased Total Cholesterol and Low-Density Lipoprotein Levels in Menopausal Women with a Body Mass Index of at Least 25 kg/m.

Lipid profile comparative analysis was performed to reveal the interdependence of lipids with () 3111T/C gene polymorphism in menopausal women with/without a body mass index (BMI) of ≥25 kg/m. Methods: A total of 193 female volunteers aged 45 to 60 years were divided into two groups: Those with BMI < 25 kg/m (control) and those with BMI ≥ 25 kg/m. Each group was then divided into two subgroups: Those with the -genotype and those with the , -genotypes. Lipid metabolism parameters were determined by the enzymatic method. Single-nucleotide polymorphisms (SNPs) were detected via polymerase chain reaction-restriction fragment length polymorphism technology. Results: There were no differences in genotypes or allele frequency between the control and main groups. In addition, there were no differences in lipid profile parameters between women of the control group and different genotypes. The total cholesterol ( = 0.041) and low-density lipoprotein cholesterol ( = 0.036) levels were higher in the subgroup of women with a BMI ≥ 25 kg/m and -genotype as compared to the subgroup with a BMI ≥ 25 kg/m and minor allele Conclusions: SNP of the gene is not associated with BMI however, data suggest that the minor allele of the gene polymorphism may have a protective role in atherogenic lipid levels in women with a BMI greater than or equal to 25 kg/m.