儿童社区获得性肺炎的有效治疗策略
Effective treatment strategies for paediatric community-acquired pneumonia.
作者信息
Atkinson Maria, Yanney Michael, Stephenson Terence, Smyth Alan
机构信息
Nottingham University Hospitals NHS Trust, Nottingham, UK.
出版信息
Expert Opin Pharmacother. 2007 Jun;8(8):1091-101. doi: 10.1517/14656566.8.8.1091.
Abstract
Pneumonia is the leading cause of death in children under 5 years of age worldwide and a cause of morbidity in a considerable number of children. A number of studies have sought to identify the ideal choice of antibiotics, route of administration and optimum duration of treatment based on the most likely aetiological agents. Emerging bacterial resistance to antibiotics is also an important consideration in treatment. However, inconsistent clinical and radiological definitions of pneumonia make comparison between studies difficult. There is also a lack of well designed adequately powered randomised controlled trials. This review describes the difficulties encountered in diagnosing community-acquired pneumonia, aetiology, treatment strategies with recommendations and highlights areas for further research.
摘要
肺炎是全球5岁以下儿童的主要死因，也是相当多儿童发病的原因。许多研究试图根据最可能的病原体来确定抗生素的理想选择、给药途径和最佳治疗持续时间。抗生素耐药性的不断出现也是治疗中需要重要考虑的因素。然而，肺炎在临床和影像学上定义不一致，使得研究之间难以进行比较。此外，缺乏设计良好、样本量充足的随机对照试验。本综述描述了在诊断社区获得性肺炎时遇到的困难、病因、治疗策略及建议，并强调了进一步研究的领域。
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