Ostrowska Lucyna, Wasiluk Diana, Lieners Camille F J, Gałęcka Mirosława, Bartnicka Anna, Tveiten Dag
Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, ul. Mieszka I 4B, 15-054 Bialystok, Poland.
Institute of Microecology, ul. Sielska 10, 60-129 Poznan, Poland.
J Clin Med. 2021 Sep 23;10(19):4317. doi: 10.3390/jcm10194317.
Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying, and changes in stool consistency. We compared the effectiveness of three different dietary treatment plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, the G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome. A total of seventy-three female patients diagnosed with a mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study. The diet of each patient in Group 1 (G1-FM) and 2 (G2-IP) was determined individually during a meeting with a dietitian. Patients from Group 3 (G3-K) received nutrition advice from a gastroenterologist. Significant differences in the reduction of IBS symptoms were found between the groups. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the G2-IP group (idiopathic abdominal pain, < 0.001; abdominal pain after a meal, < 0.001; abdominal pain during defecation, = 0.008), while in the G1-FM group, some of the IBS symptoms significantly improved (mucus in stool, = 0.031; bloating, < 0.001). In group G3-K no significant improvement was seen. Based on the results of this open-label study, it was concluded that various dietary interventions in the treatment of IBS-M patients do not uniformly affect the course and outcomes of disease management. Rotation diets based on IgG show significantly better results compared to other diets.
肠易激综合征（IBS）是一种慢性疾病，具有反复腹痛、排便紊乱和大便性状改变等症状。我们比较了三种不同饮食治疗方案（G1-FM——低发酵性寡糖、双糖、单糖和多元醇饮食，G2-IP——基于免疫球蛋白G的排除-轮换饮食，以及作为对照组的由主治胃肠病学家推荐的G3-K对照饮食）在治疗诊断为混合型肠易激综合征患者中的有效性。共有73例诊断为混合型肠易激综合征（IBS-M）的女性患者纳入该研究。第1组（G1-FM）和第2组（G2-IP）的每位患者饮食在与营养师会诊时单独确定。第3组（G3-K）的患者接受胃肠病学家的营养建议。各组之间在IBS症状减轻方面发现有显著差异。G2-IP组（特发性腹痛，<0.001；餐后腹痛，<0.001；排便时腹痛，=0.008）的IBS症状以及合并症状显著改善或完全消失，而在G1-FM组，一些IBS症状显著改善（大便中有黏液，=0.031；腹胀，<0.001）。G3-K组未见显著改善。基于这项开放标签研究的结果，得出结论：对IBS-M患者的各种饮食干预对疾病管理的过程和结果并非均有相同影响。与其他饮食相比，基于免疫球蛋白G的轮换饮食显示出明显更好的效果。
