Wang Congzhen, Fang Xiucai
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Neurogastroenterol Motil. 2021 Apr 30;27(2):153-164. doi: 10.5056/jnm20175.
Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) and account for a large proportion of consulting patients. These 2 disorders overlap with each other frequently. The pathogenesis of IBS or FD is complicated and multi-factors related, in which infectious or non-infectious inflammation and local or systemic immune response play significant roles. There are few studies focusing on the mechanism of inflammation in patients with overlap syndrome of irritable bowel syndrome and functional dyspepsia (IBS-FD). This review focuses on current advances about the role of inflammation in the pathogenesis of IBS and FD and the possible mechanism of inflammation in IBS-FD.
肠易激综合征（IBS）和功能性消化不良（FD）是常见的功能性胃肠疾病（FGIDs），在就诊患者中占很大比例。这两种疾病经常相互重叠。IBS或FD的发病机制复杂，涉及多因素，其中感染性或非感染性炎症以及局部或全身免疫反应起着重要作用。很少有研究关注肠易激综合征与功能性消化不良重叠综合征（IBS-FD）患者的炎症机制。本综述重点关注炎症在IBS和FD发病机制中的作用的当前进展以及IBS-FD中炎症的可能机制。
