Xu He-Yun, Jin Tao, Li Ren-Yuan, Ni Yi-Ming, Zhou Jian-Ying, Wen Xiao-Hong
Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Chin Med J (Engl). 2007 Apr 20;120(8):648-51.
Primary non-Hodgkin's lymphoma in lung is very rare, and the most common among them is mucosa-associated lymphoid tissue lymphoma (MALToma), whose clinical features and laboratory characteristics are poorly defined, making diagnosis difficult. The purpose of this study was to study the diagnosis and treatment of pulmonary MALToma.
The clinical data of 12 patients treated for MALToma between August 1992 and December 2005 were analyzed.
No specific symptoms or signs, or results of bronchoscopy, ultrasonagraphy or bone marrow examination could be found in the 12 patients. Only radiography was useful in diagnosis, though the final diagnosis of all the patients was based on histology and immunohistochemistry. Two patients also had gastric MALToma. Operations were performed on 6 patients, including 5 radical operations and 1 partial resection: 4 patients also received adjuvant chemotherapy. One patient experienced recurrence 152 months after the operation, while the other 5 patients have survived disease-free. Four patients were treated with chemotherapy alone, two of whom experienced complete remission and the others partial remission. The final 2 patients received no treatment and had survived for 7 and 27 months respectively. All the patients were still alive at the most recent follow-up, 7 to 160 months (mean 71.3 months).
Except radiography, no specific clinical manifestations could be identified for pulmonary MALToma. The final diagnosis should be based on histology and immunohistochemistry. Several treatment methods can be used to achieve good outcomes.
原发性肺非霍奇金淋巴瘤非常罕见，其中最常见的是黏膜相关淋巴组织淋巴瘤（MALToma），其临床特征和实验室特点尚不明确，诊断困难。本研究旨在探讨肺MALToma的诊断和治疗方法。
分析1992年8月至2005年12月间接受治疗的12例MALToma患者的临床资料。
12例患者均未发现特异性症状、体征，支气管镜、超声或骨髓检查也未发现异常。虽然所有患者的最终诊断均基于组织学和免疫组化，但仅放射检查对诊断有帮助。2例患者还患有胃MALToma。6例患者接受了手术治疗，其中5例行根治性手术，1例行部分切除术；4例患者还接受了辅助化疗。1例患者术后152个月复发，其他5例患者无病存活。4例患者仅接受化疗，其中2例完全缓解，其他2例部分缓解。最后2例患者未接受治疗，分别存活了7个月和27个月。在最近一次随访时，所有患者均存活，随访时间为7至160个月（平均71.3个月）。
除放射检查外，肺MALToma无特异性临床表现。最终诊断应基于组织学和免疫组化。多种治疗方法可取得良好疗效。
