口腔黏膜原发性恶性黑色素瘤。

Primary malignant melanoma of the oral mucosa.

作者信息

Chidzonga Midion Mapfumo, Mahomva Leonard, Marimo Clemence, Makunike-Mutasa Rudo

机构信息

Oral and Maxillofacial Surgeon, Department of Dentistry, College of Health Sciences, University of Zimbabwe, Avondale Harare, Zimbabwe.

出版信息

J Oral Maxillofac Surg. 2007 Jun;65(6):1117-20. doi: 10.1016/j.joms.2006.11.045.

DOI:10.1016/j.joms.2006.11.045

PMID:17517294

Abstract

PURPOSE

To present our experience on the epidemiology, clinical features, management, and survival of patients with oral malignant melanoma.

PATIENTS AND METHODS

Records of patients with a histologic diagnosis of primary oral mucosal malignant melanoma seen over a 23-year period were retrospectively reviewed.

RESULTS

There were 6 females and 2 males, ranging in age from 18 to 60 years; 4 cases in the maxilla, 2 in the mandible, 1 on the lower lip, and 1 on the buccal mucosa. Local recurrences developed in 2 patients who eventually died with clinical metastatic cervical nodal disease. Follow-up ranged from 6 months to 16 years 3 months. Surgery was the only treatment available.

CONCLUSION

Primary oral mucosal melanoma is rare, with a 3 to 1 female to male ratio and an average age of 41.7 years at presentation. It is most common in the maxilla and has poor prognosis despite apparent adequate local surgical control.

摘要