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口腔恶性黑色素瘤:沉默的杀手?

Oral malignant melanoma: A silent killer?

作者信息

Padhye Ashvini, D'souza Jovita

机构信息

Department of Periodontology and Oral Implantology, M.A. Rangoonwala College of Dental Sciences and Research Centre, Pune, India.

出版信息

J Indian Soc Periodontol. 2011 Oct;15(4):425-8. doi: 10.4103/0972-124X.92587.

Abstract

Oral malignant melanomas are extremely rare lesions and occur commonly in the maxillary gingiva more frequently on the palate with fewer incidences in the mandibular gingiva. Though these lesions are biologically aggressive, they often go unnoticed since they are clinically asymptomatic in the early stages and usually present merely as a hyperpigmented patch on the gingival surface. These lesions if diagnosed at an early in situ stage are potentially curable and definitely have a better prognosis, but unfortunately as they are clinically asymptomatic, it results in delayed diagnosis thus making the prognosis extremely poor. This paper presents the case of a patient who visited our department with the complaint of darkened patches on the gums and his concern was purely aesthetic. There were no symptoms associated with the hyperpigmented lesions and hence the patient did not approach us earlier. When the lesions grew larger and were unsightly, the patient has seeked dental advice. Histopathologic investigation confirmed the diagnosis as 'Oral Malignant Melanoma'. Though aggressive therapy was instilled immediately, unfortunately, the patient succumbed to death within a few months after diagnosis as the lesion was highly invasive. Due to the biologically aggressive but clinically silent nature of progression of the lesion, the importance of maintaining a high index of suspicion and early detection and diagnosis for any pigmented gingival lesions cannot be overemphasised. Diagnosis must be based on thorough detailed history and valid histologic evidence.

摘要

口腔恶性黑色素瘤是极为罕见的病变,常见于上颌牙龈,更频繁地出现在腭部,在下颌牙龈的发病率较低。尽管这些病变在生物学上具有侵袭性,但由于它们在早期临床上无症状,通常仅表现为牙龈表面的色素沉着斑,所以常常未被注意到。这些病变如果在原位早期被诊断,有可能治愈,预后肯定会更好,但不幸的是,由于它们临床上无症状,导致诊断延迟,从而使预后极差。本文介绍了一名患者的病例,该患者因牙龈上出现深色斑块前来我院就诊,其关注点纯粹是美观问题。色素沉着病变没有相关症状,因此患者之前未找我们就诊。当病变变大且有碍观瞻时,患者才寻求牙科建议。组织病理学检查确诊为“口腔恶性黑色素瘤”。尽管立即采取了积极的治疗,但不幸的是,由于病变具有高度侵袭性,患者在诊断后几个月内死亡。由于病变进展具有生物学侵袭性但临床上无症状的特点,对于任何色素沉着的牙龈病变保持高度的怀疑指数以及早期发现和诊断的重要性再怎么强调也不为过。诊断必须基于详尽的病史和有效的组织学证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2df9/3283947/0b5fc160ce32/JISP-15-425-g001.jpg

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