尼日尔的咽型脑膜炎球菌群体
Populations of pharyngeal meningococci in Niger.
作者信息
Nicolas Pierre, Djibo Saacou, Tenebray Bernard, Castelli Philippe, Stor Richard, Hamidou Amina Amadou, Boisier Pascal, Chanteau Suzanne
机构信息
Institut de Médecine Tropicale du Service de Santé des Armées (IMTSSA), WHO Collaborating Center for Reference and Research on Meningococci, BP 46, 13998 Marseille, France.
出版信息
Vaccine. 2007 Sep 3;25 Suppl 1:A53-7. doi: 10.1016/j.vaccine.2007.04.041. Epub 2007 May 7.
This study investigated the carriage of Neisseria meningitidis group W135 (NmW135) belonging to sequence type (ST)-2881, ST-11 and NmA ST-7, as these three lineages have been responsible for sporadic cases in 2003 in Niamey (Niger). ST-7 and ST-11 were also the two genotypes involved in recent outbreaks in the African meningitis belt. Among the 97 Nm isolates obtained from 287 schoolchildren swabbed three times, 1 was identified as NmA, 34 as NmW135, 8 as NmY and 54 were non-groupable (NG). Among the 86 isolates genotyped, 59.3% belonged to ST-192, 24.4% to ST-2881, 5.8% to ST-2880, 4.6% to ST-175, 3.5% to ST-4899, 1.2% to ST-11 and 1.2% to ST-7. Most of the isolates recovered were weakly pathogenic Nm NG ST-192 and NmW135 ST-2881. These results, although preliminary, are important to consider before introduction of a NmA conjugate meningococcal vaccine in Africa.
本研究调查了属于序列型（ST）-2881、ST-11和NmA ST-7的W135群脑膜炎奈瑟菌（NmW135）的携带情况，因为这三个谱系在2003年尼亚美（尼日尔）导致了散发病例。ST-7和ST-11也是非洲脑膜炎带近期疫情中涉及的两种基因型。在从287名学童中三次采集拭子获得的97株Nm分离株中，1株被鉴定为NmA，34株为NmW135，8株为NmY，54株不可分型（NG）。在86株进行基因分型的分离株中，59.3%属于ST-192，24.4%属于ST-2881，5.8%属于ST-2880，4.6%属于ST-175，3.5%属于ST-4899，1.2%属于ST-11，1.2%属于ST-7。回收的大多数分离株是致病性较弱的Nm NG ST-192和NmW135 ST-2881。这些结果虽然是初步的，但在非洲引入NmA结合型脑膜炎球菌疫苗之前进行考虑很重要。
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