O'Sullivan Sean S, Spillane Jennifer E, McMahon Elaine M, Sweeney Brian J, Galvin Roderick J, McNamara Brian, Cassidy Eugene M
Department of Neurology, Cork University Hospital, Wilton, Cork, Ireland.
Epilepsy Behav. 2007 Aug;11(1):77-84. doi: 10.1016/j.yebeh.2007.04.003. Epub 2007 May 22.
The goal of this article was to describe the clinical characteristics and outcomes of patients diagnosed with psychogenic nonepileptic seizures (PNES).
We conducted a retrospective review of patients diagnosed with PNES in a 5-year period.
Fifty patients with PNES were identified, giving an estimated incidence of 0.91/100,000 per annum. Thirty-eight were included for review, 15 of whom were male (39%). Eighteen patients had been diagnosed with epilepsy as well as PNES (47%). We demonstrated a gender difference in our patients, with males having higher seizure frequencies, more antiepileptic drug use, and a longer interval before diagnosis of PNES. Females were diagnosed with other conversion disorders more often than males. Impaired social function was observed in PNES, as was resistance to psychological interventions with a subsequent poor response to treatments.
PNES remains a difficult condition to treat, and may affect males in proportions higher than those described in previous studies.
本文旨在描述被诊断为精神性非癫痫性发作（PNES）患者的临床特征及预后。
我们对5年内被诊断为PNES的患者进行了回顾性研究。
共识别出50例PNES患者，估计年发病率为0.91/10万。38例纳入研究，其中15例为男性（39%）。18例患者同时被诊断患有癫痫和PNES（47%）。我们的患者存在性别差异，男性发作频率更高，使用抗癫痫药物更多，诊断PNES前的间隔时间更长。女性比男性更常被诊断患有其他转换障碍。PNES患者存在社会功能受损，对心理干预有抵抗且后续治疗反应不佳。
PNES仍然是一种难以治疗的疾病，可能比以往研究中描述的比例更多地影响男性。
