Ivanov A S, Torkhovskaya T I, Khalilov E M, Archakov A I
Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR, Moscow.
Biomed Sci. 1991;2(3):285-8.
Intraspecies variation in diet-induced hypercholesterolaemia in rabbits, simulating atherosclerosis, was studied. The chinchilla rabbit population examined contained several subpopulations, as indicated by polymodal forms of histograms of plasma cholesterol levels. This finding indicates that the inclusion of subpopulations in an investigation can lead to erroneous conclusions, and that subpopulations should be identified before such work is undertaken. The relationship between the molar cholesterol/phospholipid ratio in rabbit erythrocyte membranes and the plasma cholesterol level in experimental atherosclerosis was also studied. A correlation was evident only over the range of 1-5 g cholesterol per litre of plasma.
研究了家兔饮食诱导的高胆固醇血症中的种内变异，以此模拟动脉粥样硬化。所检测的青紫蓝兔群体包含几个亚群，血浆胆固醇水平直方图的多峰形式表明了这一点。这一发现表明，在调查中纳入亚群可能会导致错误的结论，并且在开展此类工作之前应识别亚群。还研究了实验性动脉粥样硬化中兔红细胞膜中胆固醇/磷脂摩尔比与血浆胆固醇水平之间的关系。仅在每升血浆含1 - 5克胆固醇的范围内存在明显的相关性。
