de Lucio Cazana F J, Rodriguez Puyol M, Perez-Caballero J, Jimenez Jimenez A, Montes Duarte A
Department of Physiology and Pharmacology, University of Alcala de Henares, Madrid, Spain.
Int J Vitam Nutr Res. 1990;60(4):392-7.
We report in the present work that membrane fluidity in erythrocytes from rats under alimentary hyperlipidemia-hypercholesterolemia is slightly diminished despite the fact that in these cells the cholesterol/phospholipid molar ratio is nearly 45% higher than in erythrocytes from control animals. In addition, the erythrocyte count in the rats given the high-fat, high-cholesterol diet was normal. Only a slight reticulocytosis was observed in these animals although their erythrocytes showed a marked decrease in their ability to extrude sodium actively. A tentative explanation for these results is proposed on the basis of other findings suggesting cellular compensatory mechanisms.
我们在当前的研究中报告，尽管在食源性高脂血症 - 高胆固醇血症大鼠的红细胞中胆固醇/磷脂摩尔比比对照动物的红细胞高近45%，但其膜流动性仍略有降低。此外，给予高脂、高胆固醇饮食的大鼠红细胞计数正常。虽然这些动物的红细胞主动排钠能力显著下降，但仅观察到轻微的网织红细胞增多。基于其他提示细胞补偿机制的研究结果，对这些结果提出了一个初步解释。
