Schlüter M, Stieltjes B, Hahn H K, Rexilius J, Konrad-verse O, Peitgen H-o
MeVis--Center for Medical Diagnostic Systems and visualisation, Bremen, Germany.
Int J Med Robot. 2005 Sep;1(3):80-6. doi: 10.1002/rcs.31.
We present a method for the detection and quantification of white matter infiltration from human brain tumours based on Diffusion Tensor Imaging (DTI). Since white matter destruction alters the local diffusion properties, DTI has the potential to sensitively detect tumour infiltration and to quantify the degree thereof. Here, we consider three tumour patients with gliomas, two with and one without contralateral tumour progress. We use DTI to identify specific fibre systems, where infiltration has to be assessed. On this basis, the problem of arbitrary region of interest definition is solved such that tumour infiltration can be reliably quantified in particular fibre bundles. It is demonstrated at the Corpus Callosum (CC) and the Pyramidal Tract (PT) that fibre bundle infiltration can be well detected by specific visualisation techniques of diffusion tensor data. Infiltration of the CC is quantified by using a reliable method for the determination of diffusion properties inside particular fibre bundles. For an age normalised quantification of white matter infiltration we introduce the Integrity Index, which measures the diffusion anisotropy inside an infiltrated fibre bundle normalised by the diffusion anisotropy in a specific region of healthy fibre tissue. It turns out that the quantification of CC infiltration correlates with contralateral tumour progression and has the potential to serve as a surrogate marker for this process, which is crucial for surgical therapy decisions and intervention planning.
我们提出了一种基于扩散张量成像（DTI）检测和量化人脑肿瘤白质浸润的方法。由于白质破坏会改变局部扩散特性，DTI有潜力灵敏地检测肿瘤浸润并量化其程度。在此，我们研究了三名患有神经胶质瘤的肿瘤患者，其中两名有对侧肿瘤进展，一名没有。我们使用DTI来识别需要评估浸润情况的特定纤维系统。在此基础上，解决了任意感兴趣区域定义的问题，从而能够可靠地量化特定纤维束中的肿瘤浸润。在胼胝体（CC）和锥体束（PT）上的研究表明，通过扩散张量数据的特定可视化技术可以很好地检测纤维束浸润。通过使用一种可靠的方法来确定特定纤维束内的扩散特性，对CC的浸润进行了量化。为了对白质浸润进行年龄标准化量化，我们引入了完整性指数，该指数测量浸润纤维束内的扩散各向异性，并通过健康纤维组织特定区域内的扩散各向异性进行归一化。结果表明，CC浸润的量化与对侧肿瘤进展相关，并且有潜力作为这一过程的替代标志物，这对于手术治疗决策和干预计划至关重要。
